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Metformin, as an AMPK activator, inhibits the AMPK-mTOR-STAT3 axis, reduces mtDNA mutations and ROS generation in lupus models, and enhances mitophagy

Electrolyte imbalance may also cause fatigue and muscle cramps

Human studies in this area are limited by small sample size and often nonrandomized character

Nevertheless, the precise cell types contributing DPP-4 to the pool targeted pharmacologically by DPP4i remains incompletely understood and may depend on the experimental model and pharmacodynamic endpoint(s) under investigation

PMID 17520591

Culture media, additives, Costar plates, and RTC were from Gibco/Thermo Fisher Scientific (Waltham, MA)