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In deficiency, the body makes abnormally large, inefficient cells (megaloblastic anemia)

Metal-catalyzed oxidation of proteins

5, SeNPs exert their anti-ferroptotic effects in renal tubular epithelial cells through a stepwise mechanism: they are first internalized into the cytoplasm via endocytosis, subsequently enriched within lysosomes, and then stimulate XBP1 expression to block I/R-induced excessive activation of NCOA4-mediated ferritinophagy, ultimately interrupting iron-dependent cell death cascades

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For subcutaneous injections, pinch the skin and poke the needle in at a 90-degree angle, almost like you're throwing a dart, so it barely goes beneath the surface

& Lang, J