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High dose oral supplementation is an effective alternative to parenteral treatment Randomized studies of daily high oral doses of 1,0002,000 g have shown equivalence or superiority to injected B 12
doi:10.1016/s0006-3223(97)00277-1
In early 2026, HHS Secretary Robert F
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Frequency: Usually given intramuscularly, ranging from daily to weekly injections
Tolerability (early human safety): Short human studies reported a placebo-like safety profile with no serious adverse events [5] [6]
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