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The advantages of SGLT2 inhibitors over DPP-4 inhibitors cannot be ascribed to differences in their antihyperglycemic effects, since in the large-scale trials, the two classes of drugs produced similar decreases in blood glucose during long-term treatment

Market & Policy Implications: A Quiet Race Is Already Starting Pharma companies may move quickly if semaglutide trials confirm benefit

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Semaglutide significantly reduces appetite, and some patients inadvertently under-eat relative to their activity level, especially as doses increase

Ozempic works primarily as a GLP-1 receptor agonist

Net prices of branded GLP-1s would have to come down further in order for them to be cost-saving within, say, a two-year time period