Kubodera, T., Yamashita, N
This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated
Lupus is a chronic autoimmune disease that affects millions of people worldwide
Lam VK, Zhang J, Wu CC, Tran HT, Li L, Diao L, Wang J, Rinsurongkawong W, Raymond VM, Lanman RB, Lewis J, Roarty EB, Roth J, Swisher S , Lee JJ, Gibbons DL, Papadimitrakopoulou VA, Heymach JV
For the exon skipping efficacy test, BC-derived primary cells (3 10 cells per well) were seeded in a 6-well plate, and the most promising AON was selected by transfecting 300 nM AON using Lipofectamine RNAiMAX reagent (Invitrogen, Thermo Fisher Scientific, #13778075) according to the manufacturers instructions
Sharing one of the products I've recently added to my skincare routine