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The oxidative stress, typically observed in pathological conditions determining endothelial dysfunction, might induce endothelial NO depletion and reduced endothelial NO availability, mediated by the interaction of reactive oxygen species with NO to generate oxidative agents potentially damaging cell DNA and proteins, namely reactive nitrogen-containing species [51], or by a direct decrease of NO synthesis, therefore suggesting potential benefit from the administration of NOS substrates, such as l-ARG, as a therapeutic strategy to increase NO production and improve CVD-related endothelial dysfunction [19, 52]

There is no TGA-registered BPC-157 product for therapeutic use in Australia, and as of June 2024 BPC-157 is a Schedule 4 (prescription-only) substance, meaning any legal supply must come through a doctors prescription via a compounding pharmacy

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Vitamin B12 (cobalamin) injections are a form of intramuscular treatment used to rapidly restore and maintain adequate B12 levels in the body