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Raw mRNA counts were log 2 -transformed, and significance was determined using 2-tailed t test

Diabetologia 69(2):466479

Four of the six genes investigated by quantitative RT-PCR were significantly up-regulated by Exendin-4 pre-conditioning, including Lactate dehydrogenase A ( Ldha ), Aldolase A ( Aldoa ), Phosphofructokinase ( Pfkp ) and Glucose-6-phosphate isomerase ( Gpi ) (Fig

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EVs are novel and important carriers of signaling molecules in vivo , and a growing body of literature highlights the important role of EVs in the intercellular transmission of pathogenic protein aggregates, thus contributing to the understanding of the pathology and clinical progression of neurodegenerative diseases (68)

It helps regulate insulin, slows gastric emptying, and signals fullness to the brain