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Aggregates of TDP-43 are found in the motor neurons of patients with ALS, suggesting that they may contribute to ALS pathogenesis

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However, dehydration can occur indirectly as a secondary consequence of common gastrointestinal side effects, such as nausea, vomiting, or diarrhea, alongside a significantly reduced drive to drink fluids due to profound appetite suppression

Brain GLP-1 agonists like semaglutide interact with neurons found in the hunger center of the brain