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doi: 10.1016/j.xcrm.2024.101719

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The mobile phase comprised of (A) 10 mM ammonium formate in 60% aqueous acetonitrile containing 0.1% formic acid and (B) 10 mM ammonium formate in 9:1 mixture of isopropanol and acetonitrile with a 0.5 mL/min flow rate maintained during a 20 min run

Given that critical protective and detoxifying role, it is not surprising that more than 25% of the body's glutathione is found in the liver with high levels also present in the kidneys, lungs, adrenal glands, reproductive organs, brain and pancreas

Glutathione is a naturally occurring compound in the human body, and oral supplementation is generally considered very safe and well-tolerated, even at higher clinical doses

As a result, they have developed different mechanisms, such as reducing membrane permeability, efflux pump inhibition, modifying the target, and producing antibiotic-modifying enzymes that enhance their antimicrobial activity 5