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The authors disrupted a cryptic internal split site in BirA and named the resulting protein BirAG

For A1C, if A1C 5% in any group

however, some studies have demonstrated limited benefits of intensive glycemic control for T2D patients as only modestly prevents or delays the progression of DPN and CAN in patients with T2D, possibly because of undiagnosed hyperglycemia and multiple combined risk factors

Reduced appetite leads to less fluid intake, nausea reduces desire to drink, and some patients experience diarrhea causing fluid loss

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