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it is whether the systemic exposure floor in humans, after dose escalation, accidental linker leakage, and long-term cumulative effects, stays below the threshold that triggers the historical PPAR liabilities
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and increased levels of TGF- compared to healthy individuals
That is a meaningful concern
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine beta-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer
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