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TS inhibition by 5FU regulates mitochondrial biogenesis through mTORPGC1 signalling 5FU has a multimodal mechanism of action: promoting DNA damage directly via its metabolite FdUTP or by inhibition of TS via FdUMP, depleting the pool of thymidine available for DNA synthesis, and causing RNA damage via FUTP (Fig

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The inhibition of ferroptosis in lung cancer stem cells and the activation of CD8 + T cells revealed the role of carnitine in tumor immune escape in the tumor microenvironment [65]

doi: 10.1111/dom.13741 53 MehrtashFDushayJMansonJE

Vegans and Vegetarians: Since Vitamin B12 is primarily found in animal-based foods, individuals following plant-based diets may have a higher risk of deficiency and can benefit from Vitamin B complex supplementation