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One hypothesis is that Ozempics effect on slowing gastric emptying may overstimulate the gastrocolic reflex, which triggers the colon to move contents along the digestive tract more quickly, resulting in diarrhea

Both are GLP-1 receptor agonists initially developed for type 2 diabetes management but have shown significant benefits in weight reduction

DOI: 10.1016/j.autrev.2009.02.020

Clinical studies have demonstrated that GLP-1 receptor agonists can reduce various inflammatory biomarkers , including: C-reactive protein (CRP) : A general marker of systemic inflammation Interleukin-6 (IL-6) : A pro-inflammatory cytokine Tumour necrosis factor-alpha (TNF-) : Another key inflammatory mediator Plasminogen activator inhibitor-1 (PAI-1) : Associated with cardiovascular inflammation The magnitude of these effects varies between studies and may depend on baseline inflammatory status, degree of weight loss achieved, and individual patient characteristics

Figure 39: Photograph of Professor Matthias Tschp, 2017 credit: Astrid Eckert / TU Muenchen, Wikipedia

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