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EECs highly express chemosensory machinery compared to non-EEC intestinal epithelial cells, including nutrient-specific G protein-coupled receptors (GPCRs) and nutrient transporters, enabling them to sense and respond to the intestinal milieu 17

Not only that, but about 90 percent of patients with chronic kidney disease go undiagnosed until the later stages of disease because the symptoms are so common and so variable

However, despite strong mechanistic and translational evidence, clinical outcomes in non-diabetic cohorts remain inconsistent

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Adequate water intake, fiber supplementation, and occasional use of gentle laxatives manage this for most people