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In this regard ApoE4 is considered detrimental, resulting in impaired copper export and elevated copper accumulation in astrocytes and neurons in vitro

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In: Parnham MJ, Bruinvels J (eds) Discoveries in pharmacology, volume I: psycho- and neuro-pharmacology

Some patients may experience transient changes in blood pressure, though long-term cardiovascular outcomes studies have generally shown beneficial or neutral effects of GLP-1 receptor agonists on cardiovascular events

p53 TAD (13-61) was subcloned into the pET His 6 glutathione-S-transferase (GST) TEV LIC cloning vector (2G-T, obtained from Scotta Gradia, Addgene plasmid #29707) and transformed into BL21 (DE3) pLysS cells