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Solutions kept at stable refrigerator temperatures generally outlast those exposed to temperature fluctuations or repeated handling, so consistent cold storage is the single biggest factor in maximizing usable shelf life

Water Solubility: Because it is highly water-soluble, it is best introduced in the aqueous phase of your formulation at a temperature below 40C to preserve its bioactivity

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10.1128/AEM.02787-06 Kim JE, Eom HJ, Kim Y, Ahn JE, Kim JH, Han NS: Enhancing acid tolerance of Leuconostoc mesenteroides with glutathione

In most cases, methylation results in the formation of biologically active molecules

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