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Altogether, these findings indicate that the antioxidant effects of metformin are achieved by Nrf2 nuclear translocation, increased downstream cytoplasmic HO-1 expression, and the subsequent activation of Nrf2 dependent signaling pathway
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2 Glutamine Metabolism in cancer Cells Glutamine is an important nitrogen resource for synthesizing amino acids and nucleotides and an important carbon source in the TCA cycle and lipid biosynthesis pathway (Figure 1) (Zhang et al., 2017
M., Roelofs, J
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