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Beyond weight outcomes, the Phase 2 obesity trial also reported improvements in several cardiometabolic markers, including: Reductions in waist circumference Improvements in fasting glucose and insulin sensitivity Favourable changes in blood pressure and lipid profiles Phase 3 trials understood to form part of the TRIUMPH programme are now underway, evaluating retatrutide in broader populations including people with type 2 diabetes and cardiovascular disease

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For a 10mg vial, adding 1mL of BAC water gives a concentration of 10mg/mL (10 units = 1mg on a U-100 syringe)

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We then used Canonical Variate (CV) analysis to identify differences in facial features between treatments and exported the raw CV scores into the publicly available Paleontological Statistics Software Package for Education and Data Analysis (PAST) analysis software ((Hammer et al., 2025) version 4.03 [ We conducted multivariate analyses of the raw CV scores using statistical methods described previously (Zelditch et al., 2012