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Forty-one years ago, on November 4, 1983, I began to synthesize GLP-1 peptides by the solid phase method in my Laboratory at the Endocrine Unit in the Bulfinch Building in Massachusetts General Hospital in Boston

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This calcium-dependent mechanism triggers rapid GH vesicle fusion and exocytosis independently of cAMP elevation, producing a fast, acute GH pulse that complements the transcriptionally-driven, cAMP-mediated GH synthesis supported by CJC-1295