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Additionally, the regimen was well tolerated with no serious AEs related to study drug and no AEs leading to study drug discontinuation

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6 In the EXAMINE trial, a safety signal for increased risk of hospitalisation for heart failure was identified with alogliptin, particularly in people with a history of heart failure

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44 In people with coronary artery disease, similar rising trends in risk of hospitalization and death have been associated with incremental increases in homocysteine levels