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Linagliptin keeps a defensible niche because its biliary excretion avoids renal dose adjustment, which matters in elderly patients with diabetic nephropathy
Only randomized trials contributed to quantitative synthesis
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The GTT indicated significantly lower blood glucose AUC in Donor+Cas9 treated mice compared to Saline and Donor groups at 8, 16, and 24 weeks post-injection, with levels comparable to non-treated mice fed with normal fat diet (Normal Diet) at matching time points
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