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The exact mechanism of the dysesthesia side effect is not known, but researchers hypothesize it may be due to the activation of the glucagon or GLP-1 receptors, as these receptors are expressed on central and peripheral nerves

According to The BMJ, doctors in India have reported a sharp rise in off-label use of GLP-1 medicines for weight loss among people without diabetes, with demand increasing despite high costs and limited medical supervision

It is also claimed to elevate the chance of ovulation and protect oocyte from DNA alterations owing to oxidative damage

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(1992, Biochem J) demonstrated that IGF-1 and its variants including Long R3 IGF-1 are anabolic in dexamethasone-treated rats, confirming the utility of IGF-1 LR3 in models of catabolic states and muscle wasting where native IGF-1 activity is suppressed by glucocorticoid-driven IGFBP upregulation