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In addition to the therapeutic applications of FUS-induced BBB opening, it can also be used to enhance the delivery of PET tracers into the brain (including antibody-like, carbohydrate, or glycolipids tracers) to enhance neuritic plaque/neurofibrillary tangle binding, which will provide improvements in the detection sensitivity and specificity for early diagnosis of Alzheimers disease

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Systemic glutathione depletion, combined with elevated ROS, damages the endothelial lining of the blood vessels

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