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Pro-fibrotic markers yes-associated protein 1 (YAP1) and taffazin (TAZ) and autophagy marker p62 showed elevated expression in Gclc L-KO mice (Fig
Fourteen days after UUO, the AAV-Ctrl-injected mice presented decreased GPX4 expression and accumulation of lipid hydroperoxide (4-HNE)- and TUNEL-positive cells, as detected by immunofluorescence and TUNEL assays (Sup
These carriers optimize drug delivery efficiency, prolong action duration, and activate multi-target anti-inflammatory pathways, demonstrating superior local efficacy and symptomatic relief compared to conventional administration in rodent and rabbit gout models
Oxidative Medicine and Cellular Longevity, 2022 (1), 5961123
Its even linked to higher pregnancy rates 12
Colocalization analysis is based on five hypotheses: (i) absence of any causal variant influencing either protein expression levels or migraine within the genomic region (H0)
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