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It is not yet FDA approved, but Phase 3 data from the TRIUMPH-4 trial (December 2025) showed an average of 28.7% body weight loss at 68 weeks at the 12 mg dose the highest ever recorded in a pharmacological weight loss trial

(58) described a positive correlation between body mass index (BMI) and adipose tissue UCP-2 expression

Together, these medications provide robust HbA1c reduction with minimal hypoglycaemia risk, making them particularly valuable for patients requiring treatment intensification beyond metformin-based therapy

reports research grant support, on behalf of their institution, from Novo Nordisk and advisory/consultancy fees from Boehringer Ingelheim, Eli Lilly & Company, Gila Therapeutics Inc, GLW-01, International Medical Press, Novo Nordisk, Pfizer and ViiV

This usually improves over time

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