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Healthcare professionals should: Advise patients about the lack of evidence supporting HCG Explain the risks of severe caloric restriction Discourage combining unlicensed treatments with prescribed medications Offer evidence-based alternatives within NHS weight management services Professional responsibility : Prescribers have a duty to follow GMC guidance on prescribing unlicensed medicines, which requires clear justification and informed consent

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Viennois and colleagues (Cell Mol Gastroenterol Hepatol, 2016, PMID 27458604) reported that the effect was lost in PepT1-knockout mice, making the transporter the gating step

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