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The Braak hypothesis proposes that PD exhibits a multifocal and multitransmitter-driven pathology, providing a framework for understanding its neuropathological progression ( -syn pathology is observed not only within the brains dopaminergic and non-dopaminergic systems but also extensively throughout the peripheral and autonomic nervous systems

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Causes: Venoocclusive disease: Chemotherapeutic agents, bush tea Peliosis hepatis: Anabolic steroids Hepatic vein thrombosis: Oral contraceptives Neoplasm [edit] Neoplasms have been described with prolonged exposure to some medications or toxins