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If youve experienced queasiness or digestive discomfort while on these medications, youre not alone

Call your provider if reactions are severe, spreading, or do not improve

Indeed, the most frequent pathogenic variants in the SCL12A3 gene are those that result in lack of proper glycosylation of the NCC protein which prevents its trafficking to the membrane or interferes with its ability to transport Na + and Cl

An uncommon serious side effect is an inflamed pancreas (acute pancreatitis)

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But it can take up to 12 weeks (3 months) to understand if the med is truly working for you