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355(j)) and manufacturing challengespeptide synthesis and pen devices are complex
Two more papers were excluded from the review since because they reported data from the same sample as another included paper
Zhao X, Wang M, Wen Z, Lu Z, Cui L, Fu C, Xue H, Liu Y, Zhang Y
(2015) 310:F1237
but with the drug, they increased by only $1,000
The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
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