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Non-medicinal ingredients: Hypromellose (vegetable capsule shell), microcrystalline cellulose, magnesium stearate (vegetable source)

The authors thank Lene Wither Takla (Novo Nordisk A/S, Global Drug Discovery, Denmark) for expert technical assistance with conducting the animal studies, Heidi Solvang Nielsen (Novo Nordisk A/S, Global Drug Discovery, Denmark) for dissection of the hippocampus for RNA-seq and histology, as well as Esther Bloem and Susanne Jrgensen for assistance with protein assays (Novo Nordisk A/S, Global Research Technologies, Denmark)

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Exenatide GLP-RA , 1995 2005 .60 Liraglutide 2010 2 ,62 lixisenatide 2013 2 , 2 016 7 .63 (Albiglutide) 2014 3 , 2014 4 .64 (Dulaglutide) 2014 9 T2DM ,65 (Semaglutide) 2017 9 .66 (Beinaglutide) GLP-RA , 2016 9 T2DM .67 PEG-(PEG-loxenatide) GLP-RA , 2019 5 .66 ( 1 2) Table 1 Comparison of GLP-1RAs used in type 2 diabetes mellitus DateBrand nameGLP-1RAHalf-lifeDose (SC)Molecular formulaClinial trial focus Table 2 Comparative overview of efficacy and adverse effects of mainstream GLP-1RA medications Current GLP-1RAs GLP-1RAs are synthetic protein preparations that have partial or complete amino acid sequence homology with GLP-1 found in the body, are not easily degraded, have longer half-lives and have stronger biological activity

Amgen has provided limited information about the drug, including its mechanism of action

Nearly all of my clients are women in perimenopause or menopause