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We also have to stop our system-by-system treatment approach

Even though leptin receptors are expressed on both neuronal populations, leptin stimulation of NPY neurons decreases their firing and attenuates food intake, whereas its actions on POMC neurons are opposite (Pandit et al., 2017)

He noticed that his shirt and trousers were damp, as was his hair, face, and arms

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These effects resolve with dose reduction but indicate levels beyond physiological optimization