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433 Further investigation into the mechanism underlying the alcohol-reducing effects of semaglutide suggested that this effect may involve the modulation of alcohol-induced rewards and punishments within the brain

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In juvenile rat hippocampal slices, pyruvate administration was able to restore ATP levels and rescue neurons against NMDA mediated excitotoxicity (Izumi and Zorumski, 2010)

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Inflammatory microglia have several deleterious effects, including shifting astrocytes from a protective to an inflammatory phenotype via the secretion of extracellular vesicles and cytokines, such as IL1a, TNF, and C1q