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Mediation analysis indicated that weight loss did not attenuate the treatment effect on MACE, while changes in waist circumference accounted for approximately one-third of the cardiovascular benefit

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AKT phosphorylation at Ser473 did not change in cells treated with 1 M of U0126 but dramatically increased when cells were treated with 5 or 10 M of U0126 (Fig

Public statements and announcements do not constitute completed regulatory action until formally published by the FDA

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Clarification of a number of important, unresolved concepts will be dependent on the outcomes of future targeted research