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195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death

barbarum did not affect lipid or glucose metabolism markers

Unused reconstituted solution, used syringes, and empty vials should be collected in designated sharps containers and chemical waste bins rather than general laboratory trash