Obesity is associated with pronounced disruption in circadian clock gene expression within adipose tissue 1,10
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Despite the pharmacokinetic limitations, irregular adsorption and fast catabolism, the l-dopa became the standard oral pharmaceutical therapy of PD in the last fifty years [7]
As mentioned above, decreased Nrf2 expression and protein levels, and concomitantly, a lower activity of antioxidant defense, are found in tissues from COPD patients
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Whereas the oxidation of selenenic acid to seleninic acid is reversible in the presence of GSH, the further oxidation to selenonic acid may inactivate the enzyme