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Metformin toxicity can be categorized into metformin-associated lactic acidosis (MALA), metformin-induced lactic acidosis (MILA), and metformin-unrelated lactic acidosis (MULA) (Rivera et al., 2023)

Tirzepatide's greater weight-loss efficacy comes with a 54% higher chance of crossing into Depletive territory

They also work well when spacing intake makes more sense than eating larger portions

Several challenges remain to be addressed

Through individualized planning and access to additional resources, it is possible to prioritize both maternal and fetal health, even when stopping a medication like Semaglutide is necessary

In the STEP program, participants who stopped semaglutide regained approximately two-thirds of their weight loss over 52 weeks, while others maintained modest gains