semaglutide vs tirzepatide hair loss GLP-1 receptor agonists (semaglutide, tirzepatide) are associated with a small but real increase in shedding. In most cases, this represents telogen effluvium driven by rapid weight loss, not direct follicular toxicity Weight loss with retatrutide1, tirazepatide2,

Sauter M, Uhl P, Majewsky M, Fresnais M, Haefeli WE, Burhenne J

Staying well-hydrated is crucial while on semaglutide

R Clinical genetics resources: PharmGKB (pharmacogenomics knowledge base): pharmgkb.org CPIC (Clinical Pharmacogenetics Implementation Consortium) guidelines for UGT1A1, NAT2, TPMT: cpicpgx.org Conjugation pathway substrates and testing: The Hepatic Detox Profile (caffeine/aspirin/acetaminophen challenge) is the gold standard functional test for Phase I/II conjugation capacity in clinical practice

Most users report maintained or only slightly reduced workout performance during their cycle

Senescent glia link mitochondrial dysfunction and lipid accumulation

Muscle also drives your resting metabolic rate , lose a meaningful amount of it and you burn fewer calories at rest, which is part of why weight regain after stopping can be so stubborn