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Safety Profile: What We Learned About Side Effects Common Adverse Events The TRIUMPH-4 trial confirmed that retatrutide's side effect profile aligns with other incretin-based therapies, with gastrointestinal symptoms being the most common: Incidence of GI Side Effects (12mg dose): Nausea: 43% (vs 11% placebo) Diarrhea: 33% (vs 13% placebo) Vomiting: 21% (vs 0% placebo) Constipation: Elevated vs placebo Decreased appetite: Common Most gastrointestinal side effects were mild to moderate in severity and occurred primarily during the dose escalation phase

Your starting tirzepatide dose is based on your current semaglutide dose, tolerability, and weight loss response

I know it sounds unbelievable but I swear, I really noticed this effect

Epub 2017 Aug 15

Less common effects include headaches , fatigue , and feeling cold

Chew well before swallowing