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WARNINGS Patients with early Lebers disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy

The honest summary is that long-term human safety data is missing and the angiogenesis mechanism is an unresolved theoretical concern

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doi: 10.1136/bmj.m1086 15 De FloraS.GrassiC.CaratiL

The endocrine system doesn't operate through isolated commands, it functions through coordinated feedback, precise timing, and signaling pathways that continuously interact