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The gene set enrichment analysis (GSEA) of gene ontology (GO) pathways of RNA sequencing data revealed that T315I-Bcr-Abl cells have an increase in ATF4-mediated integrated stress response (ISR) signaling (Supplementary Fig
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26 This marked a significant advancement in obesity treatment research, especially in combining multiple drug targets
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However, insulin sensitivity and glucose tolerance were maintained, likely owing to an increased conversion of saturated fatty acids (known to cause insulin resistance) to monounsaturated fatty acids mediated by stearoyl-CoA desaturase-1 (SCD1) [52]
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