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Bupropion is an antidepressant that reduces appetite, while naltrexone helps control cravings (its prescribed alone to treat certain addictions)

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The researchers examined the lifestyle habits, GLP-1 RA usage, and cardiovascular health outcomes of more than 98,000 adults living with T2D and without any prior cardiovascular disease, using data from the Veterans Affairs Million Veteran Program from 2011 to 2023

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What sets Stage 3 apart clinically is that even small stressors may trigger an adrenal crash, and each crash may take longer to recover from than the last, without fully returning the body to its previous baseline