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Even when a small fraction does reach the viable epidermis, the molecule has a short functional half-life unless it is stabilized in the formulation (encapsulation, copper chelation, or both) 1

Patients who have experienced shedding should discuss it with their clinician rather than stopping medication on their own

Rather, it causes the production of melanin to include pigments of lower pigmentation that persist and decrease excess pigmentation progressively

Peer review Peer review information Nature Communications thanks Rudolf Oehler, Robert Hoffman and the other, anonymous, reviewer(s) for their contribution to the peer review of this work