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A catalytic cycle of GPx (Figure 2) starts with the oxidation of the selenol (ESeH) moiety of Sec residue by peroxide to generate the selenenic acid (ESeOH) [37, 38], which reacts with cellular thiol (glutathione, GSH) to generate a selenenyl sulfide intermediate (ESeSG)
Fatty acids are constituents of phospholipids needed to create cell membranes and nucleotides 29,30
doi: 10.3390/polym12102403 37 MallmannMPOliveiraMS
You cannot reasonably expect a positive outcome with the primary treatment if you do not do all in your power to maximize the chances of success
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