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A placebo-controlled human study therefore adds more useful information than an uncontrolled case report or mechanistic hypothesis.The reported separation between groups and the return of symptoms after treatment ended support further study of symptom control and durability

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41589_2021_915_MOESM17_ESM.mpeg Supplementary Video 15 Representative movie for 100 ns MD simulation of oxidized GPX4 U46C-K48L (C46-SOOO-) with the camera zoomed in for a close-up of the active site

The Paneth cell marker LYZ was significantly upregulated in patient hIECs, indicating increased Paneth cell differentiation

doi:10.1038/s41598-017-14071-y

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