Key safety observations from Phase 2 data include: Gastrointestinal side effects were the most commonly reported adverse events Dose-dependent tolerability issues were noted, particularly at higher doses, with meaningful discontinuation rates Increases in heart rate were observed, consistent with the known class effect of GLP-1 receptor agonists
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daily pills like Phentermine and Metformin) Final Thoughts: The Best Choice for Weight Loss While Phentermine, Topamax, and Metformin have played roles in weight management, they are limited by side effects, modest weight loss, and long-term risks
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GLP-1 receptor agonists, represented by semaglutide (in Wegovy and Ozempic) and tirzepatide (in Mounjaro), are currently the most widely used obesity treatments
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