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The role of the HIF-1/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer

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Animals were dosed subcutaneously with IcoSema (2100 nmol/mL icodec and 490 nmol/mL semaglutide) at a single dose containing 3.75 nmol/kg icodec and 0.875 nmol/kg semaglutide with addition of either 0.2 mmol/L PSA ( N = 8) or 2.1 mmol/L SFAD ( N = 8) to the formulation