In addition to GLP-1 mediated effects, DPP-4 inhibitors may have CV protection through GLP-1-independent mechanisms, including inhibition of degradation of other DPP-4 substrates such as gastric inhibitory peptide (GIP) and SDF-1 [12, 14, 31]
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Research Links Weight Loss Medication to Improved Sleep Apnea According to a recent Guardian article, a weight loss drug appears effective in alleviating sleep apnea in obese patients
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In the prescribing information, the tablet dosing schedule steps up from 1.5 mg 4 mg 9 mg 25 mg over time to help tolerability
doi:10.1073/pnas.1221585110 Hollenstein K, de Graaf C, Bortolato A, Wang MW, Marshall FH, Stevens RC