Overlap between GLP1RA-related metabolites We found that metabolites shared between analyzed GLP1RA networks are associated with Galactose metabolism (ATP, ADP, alpha-D-Glucose, D-Fructose, D-Glucose, Glucose 6-phosphate, Pyrophosphate, Sucrose, Water), neomycin, kanamycin and gentamicin biosynthesis, starch and sucrose metabolism, arginine and proline metabolism but also nitric oxide-related pathways, platelet homeostasis (ATP, ADP, citrulline, cyclic GMP, guanosine triphosphate, hydrogen ion, L-arginine, NADPH, nitric oxide, oxygen, pyrophosphate) and VEGF-related pathways (ATP, ADP, citrulline, guanosine triphosphate, hydrogen ion, L-arginine, NADPH, nitric oxide, oxygen)
Last updated May 18, 2026
Among the outcome estimates, significant reductions were reported in 13 of 17 for major adverse cardiovascular events (MACE), 5 of 8 for cardiovascular mortality, 3 of 4 for cardiovascular disease (CVD) events, 1 of 3 for cardiovascular death, and 1 of 1 for composite cardiovascular outcomes
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Metabolic rate changes
Widely used as an active ingredient in cosmetic and skincare formulations
