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Earlier evaluation is warranted with known risk factors such as irregular menses, amenorrhea lasting more than 3 months, severe male factor, endometriosis, or pelvic disease

Severe hypoglycemia was not reported, and only one unrelated death occurred during the study

They are frequently prescribed for conditions like atrial fibrillation, deep vein thrombosis, or following major surgeries

The landscape of DKD treatment has dramatically changed in the past 10 years

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In brief, we used nationwide health and administrative registers in Sweden, Denmark and Norway, including population registers and Statistics Denmark/Statistics Sweden (vital status, demographics, socioeconomic variables), patient registers (comorbidities, outcomes), prescription registers (study drugs, co-medications) and the national cancer registers (outcome)