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Search terms included relevant keywords and controlled vocabulary (e.g., MeSH and Emtree terms) for T2DM, GLP-1 receptor agonists, multi-target agonists, and gastrointestinal outcomes, combined with terms for randomized controlled trials

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Quality assessment To evaluate the risk of bias in both prospective and retrospective studies included in our review, two researchers (Yanni Yao and Nairong Liu) utilized the NewcastleOttawa Scale (NOS) [24] to assess the quality of each article

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7RA3: Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW